Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D’Anca M, et al. Alternative splicing: new insights from global analyses. miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells. Rasmussen MH, Lyskjaer I, Jersie-Christensen RR, Tarpgaard LS, Primdal-Bengtson B, Nielsen MM, et al. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al. 5-fluorouracil: mechanisms of action and clinical strategies. DNA repair pathways as targets for cancer therapy. Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA. a personalized approach to clinical decision making. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Thus, measuring and targeting CACClnc and its associated pathway could yield valuable insight into clinical management and might ameliorate CRC patients’ outcomes.īray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. In addition, expression of exosomal CACClnc in peripheral plasma of CRC patients can effectively predict the chemotherapy effect of patients before treatment. Mechanistically, CACClnc specifically bound to Y-box binding protein 1 (YB1, a splicing factor) and U2AF65 (a subunit of U2AF splicing factor), promoting the interaction between YB1 and U2AF65, and then modulated alternative splicing (AS) of RAD51 mRNA, and consequently altered CRC cell biology. CACClnc promoted CRC resistance to chemotherapy via promoting DNA repair and enhancing homologous recombination in vitro and in vivo. In this study, we identified a novel lncRNA, CACClnc, which was upregulated and associated with chemoresistance and poor prognosis in colorectal cancer (CRC). However, the effect of lncRNA on chemoresistance and RNA alternative splicing remains largely unknown. Yeaaaah mate! A brutal slice of midnight from a fellow Mancunian.Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis. Meat-punching percussion is an added bonus (really). Listen to this at considerable volume, and then listen to rest of Trilogie De La Mort.Ī thing of architectural beauty and one of my absolute favourites. Éliane Radigue - Kyema (Intermediate States) Alchemical, the combination a keen ear and a playful mind (and vice versa). This was the first piece by Parmegiani that I heard and still my favourite. I've borrowed these bass drums.Ī lesson in pacing and hybridised layering. The awesome mix of the sampled, the synthesised and the acoustic/performed. It's on this list because of the sound and pattern of the bass drums. There's a lot to be loved and longed for here. The composition verses improvisation debate (finally!) neutered. With Ninh one learns to find proportions as inherent qualities of the materials as they interact and as a function of a permanently developing intuition. Lê Quan Ninh - La Ville Et Das Sinusoïdes à Petit BudgetĪnything by Ninh. I'm amazed by the textural beauty of his practice. I dislike recordings of birds in electroacoustic music except for this one. Hanna Hartman - Message From the Lighthouse Five bars into the piece and you're in a different universe. This is what I call a ‘teleportation piece’. Here’s sneaky peek into the sounds that have influenced their choices… Supported by Sound and Music in partnership with Arts Council England and BBC Radio 3, the two-day bonanza promises an immersive, experimental, and sometimes inexplicable sonic journey in the future of music. Wow! Distractfold Ensemble’s Linda, Sam and Mauricio have turned in quite possibly the most eclectic and out-there playlist we’ve hosted yet.Īhead of the Cut & Splice Festival they’re hosting in Manchester on 10 and 11 March, they’ve picked out their ‘curational inspirations’ – a wonky bunch of electronics, experimental noise, post-classical, pop and techno to delight and bewilder.ĭetermined to test our listening abilities by revealing hidden sonorities in instruments, objects and the city, the ensemble has brought together pieces from today's most forward-thinking sonic artists for Cut & Splice 2017.
0 Comments
Leave a Reply. |